Our findings in Dahl-salt-sensitive and Dahl salt-resistant rats support prior research showing sex-specific T-cell effects in the pathophysiology of hypertension. Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure Kurt R. Stenmark, Barbara Meyrick, Nazzareno Galie, Wolter J. Mooi, and Ivan F. McMurtry University of Colorado Denver, Aurora, Colorado Submitted 1 July 2009; accepted in final form 4 September 2009 Tachycardia-induced cardiomyopathy: a review of animal models and clinical studies. • It should consume minimal quantities of compounds. Consequently, a vast list of The ideal animal model for hypertension research should have human-like cardiovascular anatomy, hemodynamics, and physiology . Animal models have been developed to study the effects of drugs that can affect cardiovascular diseases, including hypertension. 10. In this Review, Clauss and colleagues summarize the advantages and . A meta-analysis was performed of 291 publications discussing the efficacy of 611 inte … The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies. Animal models of hypertension: An overview. In addition to primary papers from world-renowned experts, the Journal contains authoritative reviews that summarize and evaluate the most significant recent developments. of an animal model for investigating disparate myocardial effects of obesity and hypertension. We aim to assess the inflammatory and hemodynamic responses to CIH and examine the effects of etanercept, anti-TNF, in an animal model of OSA/CIH-induced PH. small-animal models can be strain-specific with significant inter- and intra-species variation, and/or have accelerated disease progression not consistent with clinical presentation (2, 3, 10). Gomal ournal of Medical Sciences April-une 214, ol. BioMedResearchInternational 3 ofhypertension[24].Sinceanimalmodelsofhypertension areamimicryofhumanhypertension,manyofthesemodels . To date, the pathogenesis of CTEPH remains unexplained. Genetic hypertension in rats 8. the availability of genetically modifi ed animal models. This helps you give your presentation on Hypertension in a conference, a school lecture, a business proposal, in a webinar and business and professional representations.. Development of experimental models of hypertension allowed dissection and isolation of various factors associated with regulation of blood pressure, inheritance of hypertensive traits . 158 PDF View 2 excerpts, cites background ANIMAL MODELS OF HYPERTENSION, DIABETES AND DIABETIC HYPERTENSION: AN OVERVIEW G. Jadhav, R. Saudagar, C. Upasani models can be exacerbated by the addition of risk factors such as hypertension or diabetes. Vaccination provides a promising approach for treatment of hypertension and improvement in compliance. Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening disease due to pulmonary artery obstruction by persistent organised clots related to one or more episodes of acute pulmonary embolism. hypertension: animal models Olaf Mercier and Elie Fadel ABSTRACT: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening disease due to pulmonary artery obstruction by persistent organised clots related to one or more episodes of acute pulmonary embolism. • Should be able to predict the potential antihypertensive properties of an agent. Animal models of primary hypertension Interestingly, spontaneous development of high BP without any pharmacological or surgical intervention may occur in individual animals. • It should be able to predict the potential antihypertensive properties of an agent. A summary of the selection of animal models for the study of hypertension of developmental origins is An ideal PH model should manifest the key clinical, hemodynamic and histopathological features of human PH [7]. The most The Here, the ATRQβ-001 vaccine, a peptide (ATR-001) derived from human angiotensin II (Ang II) receptor type 1 conjugated with Qβ bacteriophage virus-like particles, was developed and evaluated in animal models of hypertension. This may be due to the amount of published physiological data, relative small size, and robust responses seen in some genetic strains. The models of . 12, No. animal models and human subjects did not show consis-tently elevated plasma rennin levels. Using an animal model, the rats were induced with PAH by the injection of monocrotaline (MCT), a pyrrolizidine alkaloid derived from Crotolaria spectabili s [15]. An ideal animal model of hypertension criteria • It should be feasible in small animals. An animal model has been developed to study hypertension and atherosclerosis for several reasons. • It should be comparable to some form of human hypertension. In conclusion, animal models for hypertension and atherosclerosis are invaluable in improving the authors' understanding of cardiovascular disease and developing new pharmacological therapies. Animal models of PAH secondary to other causes such as left heart disease, lung disease, or thromboembolism (WHO groups 3-5) [2] were excluded. Genetically modi-fied animals and neonatal animal models were also excluded. In the selection of an animal model for the study of portal hypertension some general concepts, which apply to every animal model, must be considered[4] (Table 1). Mice have become widely used as models of human atherosclerosis as they offer advantage compared with otherspecies (Table 1 ). Animal Models and Experimental Medicine is a new open access journal dedicated to disseminating research and contemporary information in the field of laboratory animal sciences. Various models of cardiac arrhythmia have been developed in several different animal species to study the mechanisms of disease. Animal models have allowed detailed study of hemodynamic alterations typical of portal hypertension and the molecular mechanisms involved in abnormalities in… Salt-Sensitive Hypertension: Lessons From Animal Models Paul W. Sanders 0 The underlying etiology of salt-sensitive hypertension has been elusive, in part because the term represents a syndrome rather than a specific disease entity and in part because of the difficulty in completely defining the characteristics of the syndrome. Exacerbation of adverse cardiovascular effects of aircraft noise in an animal model of arterial hypertension Sebastian Stevena,b,1, Katie Frenisa,1, Sanela Kalinovica, Miroslava Kvandovaa, Matthias Oelzea, Johanna Helmstädtera, Omar Hahada,i, Konstantina Filippoua, Kamil Kusc, Chiara Trevisand, Clearly, investigators need to make informed choices as to the appropriate animal model for specific application, and the experiments need to be carefully designed, executed, and . Pulmonary endarterectomy removes obstruction from pulmonary vessels and can cure patients. clinical research. In the past few years, physiological outcomes in established animal models of . in an animal model of portal hypertension gastropathy (¨) Camila Marques,* José L. Mauriz,§ Douglas Simonetto, † Claudio A. Marroni, † María J. Tuñon, § Javier González-Gallego, § Norma P. Marroni*,‡ * Universidade Federal do Rio Grande do Sul-UFRGS. This observation has contributed to the creation of genetic animal model of hypertension and enabled The reason for the I. High Energy Ration Feeding in Steers at Low Elevation: A Natural Animal Model of Irreversible Pulmonary Hypertension, Pulmonary Arterio-Venous Remodeling, and Heart Failure 1. The LDLR−/−mouse represents a model of familial hypercholesterolemia due to one of the Induced intraocular hypertension animal models are very promising in terms of a better understanding of the pathophysiologic processes of glaucoma, as well as in the discovery of novel therapies for this condition. Further studies are needed to Animal Models of Pulmonary Hypertension: Matching Disease Mechanisms to Etiology of the Human Disease Kelley L. Colvin1,2,3,4 and Michael E. Yeager *1,2,3,4 1Deptartment of Pediatrics-Critical Care, University of Colorado Denver, USA 2Cardiovascular Pulmonary Research, USA 3Department of Bioengineering, University of Colorado Denver, USA 4Linda Crnic Institute for Down Syndrome, USA the do- embolization.55 in 1939, page56 developed a model of mestic pig is a good large animal model of hypertension hypertension obtained by wrapping the kidney in cel- and end-organ injury46 because the anatomy and phys- lophane or silk, which lead to perinephritis and renal iology of its renal47 and cardiovascular48 systems are parenchymal … Because the etiology of essential hypertension is not known and may be multifactorial, the use of experimental animal models has provided valuable information regarding many aspects of the disease, which include etiology, pathophysiology, complications and treatment. Hypertension is a multifactorial disease involving complex interactions between genetic and environmental factors. Salt-Sensitive Hypertension: Lessons From Animal Models Paul W. Sanders 0 The underlying etiology of salt-sensitive hypertension has been elusive, in part because the term represents a syndrome rather than a specific disease entity and in part because of the difficulty in completely defining the characteristics of the syndrome. This model has been developed in the rats (4,5,35), mice (9, 14) and rabbits(3). BPD is a significant pediatric health problem because, developed: large-animal models and small-animal models. • It should be simple to perform and uniformly reproducible. This study evaluates the effect of hydro-alcoholic celery leaf extract onsystolic blood pressure (SBP), heart rate (HR) and lipid profile in animals' model of hypertension induced by fructose. Several models have been developed to address cardiovascular complications, including atherothrombotic and cardiac diseases, and . To date, the pathogenesis of CTEPH remains This review discusses those preclinical models that meet the clinical definition of preeclampsia, where maternal hypertension, together with proteinuria, other maternal organ dysfunction, and intrauterine growth restriction are present. The animal models of hypertension share many features which are common to human hypertension. 2 115 STEROID INDUCED OCULAR HYPERTENSION: AN ANIMAL MODEL Saadat Ullah Khan1, Mohammad Ashraf2, Abdul Salam2, Zulfiqar Ali3, Mehboob Ur Rahman4, Abid Shah3 1Department of Pharmacology, Khyber Medical College Peshawar, 2Department of Pharmacology, Bannu Medical College Bannu, 3Department of Ophthalmology Ayub Medical College . Animal model evaluation of a novel renal denervation system for future laparoscopic treatment of resistant hypertension Won Hoon Song, 1, 2, * Jinhwan Baik, 3, * Sunchoel Yang, 4 Eue-Keun Choi, 5 Sung-Min Park, 3 and Chang Wook Jeong 1: 1 Department of Urology, Seoul National University Hospital, Seoul, Korea. to the animal species used, and different models can vary in their response to experimentally induced modifications.11 The appropriate selection of the experimental model should be based on the purpose of the study, that is, the model that is best suited to the research aims, although various factors may influence this Widely distributed and discoverable globally with indexing by ESCI, MEDLINE, PubMed via PMC, and Directory of Open Access Journals. The features of the animal models described within the field of PH research, either the physical, chemical and genetic models, are summarized, emphasizing its advantages and limitations. Animal Models of Preeclampsia. Many of these models have been developed by utilizing the etiological factors that are presumed to be responsible for human hypertension such as excessive salt intake, hyperactivity of renin angiotensin- 7.aldosterone . almost four decades after its initial description (134), this Large-animal models provide unique opportunity for physio- disease of preterm infants remains the most common cause of logical studies of evolving disease pathogenesis in . EDUCATIONAL FORUM: Year : 2003 | Volume: 35 | Issue: 6 | Page: 349-362: Animal models of hypertension and effect of drugs DK Badyal, AP Dadhich, H Lata . : 2 Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea. J Am Coll Cardiol 1997; 29: 709-715. It recognizes a new independent investigator working in hypertension or cardiovascular research who has significantly contributed to our understanding of the causes of hypertension and related cardiovascular disease. 64(3): 1094-1097, 1988.-An experimental model for investigating the disparate effects of obesity and hypertension on the heart was developed by ligation of the aorta of male Sprague-Dawley rats made In this review, definition, pathology, prevalence, pathogenesis, . The uploader spent his/her valuable time to create this . Animal Models of Pulmonary Hypertension: Matching Disease Mechanisms to Etiology of the Human Disease Kelley L. Colvin1,2,3,4 and Michael E. Yeager *1,2,3,4 1Deptartment of Pediatrics-Critical Care, University of Colorado Denver, USA 2Cardiovascular Pulmonary Research, USA 3Department of Bioengineering, University of Colorado Denver, USA 4Linda Crnic Institute for Down Syndrome, USA 3 1. • Simple to perform and uniformly reproducible. This study evaluates the effect of hydro-alcoholic celery leaf extract onsystolic blood pressure (SBP), heart rate (HR) and lipid profile in animals' model of hypertension induced by fructose. The utility of animal models for improving the understanding of the pathogenesis, prevention, and treatment of hypertension and its comorbidities depends on their validity for representing human forms of hypertension, including responses to therapy, and on the quality of studies in those models (such as reproducibility and experimental design). Blood vessels and cardiac tissue samples can be taken for detailed experimental and biomolecular examination. This review will cover the most commonly used animal models of portal hypertension and their relative utility for the study of different aspects of this syndrome. review, we discuss the roles of various animal models in PH research, describing how they have contributed to the Table 1. T-cell function in female animal models of hypertension is poorly understood since most research is conducted in males. animal models for hypertension assessment are introduced. Pulmonary hypertension (PH) is a multifactorial disease, commonly associated with heart failure. Moreover, Sharma et al. Objectives: Hypertension is one of the most common diseases of the modern era. hypertension and consequently, inclusion of this entity when discussing secondary hypertension is appropriate. an animal model of hypertension through modula - tion of CD39þ and CD73þactivities and A 2A receptor expression Andre´ ia Machado Cardoso1,2,3, Leandro Henrique Manfredi1, Daniela Zanini2, Margarete Dulce Bagatini1, Jessie´ Martins Gutierres2, Fabiano Carvalho2, Alain Tremblay 3,4, Adriane Bel- Because of the . MODELS OF EXTRAHEPATIC PORTAL HYPERTENSION: Portal Vein Stenosis Model: The most common animal model of prehepatic portal hypertension currently used is partial portal vein ligation. Pulmonary hypertension (PH) is increasingly recognized in otherwise healthy obese individuals (BMI>30 kg/m 2), in fast-growing broiler chickens, and in beef a naturally occurring large animal model of obesity-associated pulmonary hypertension with left heart disease Greta M. Krafsur 1,2,3 , Joseph M. Neary 4 , Franklyn Garry 5 , Timothy Holt 5 , Daniel H. Gould 2 , There are general limitations of small animal models, including the areas of studying breathing mechanics, gas exchange, and pulmonary hemodynamics, 61 especially catheterization. An animal model has been developed to study hypertension and atherosclerosis for several reasons. Research Article Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension James West1, Xinping Chen1, Ling Yan2, Santhi Gladson1, James Loyd1, Hamid Rizwan2 and Megha Talati1 1Division of Respiratory and Critical Care, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; 2Division of Medical Genetics Research Article Challenges in the development of chronic pulmonary hypertension models in large animals Abraham Rothman1,2, Robert G. Wiencek3, Stephanie Davidson4, William N. Evans1,2, Humberto Restrepo1,2, Valeri Sarukhanov1 and David Mann5 1Children's Heart Center Nevada, Las Vegas, NV, USA; 2University of Nevada, School of Medicine, Department of Pediatrics, Las Vegas, NV, USA; 3Stanford we studied cgrp in three animal models of hypertension: 1) deoxycorticosterone-salt (doc-salt) model, a model in which the rat undergoes a uninephrectomy followed by excess mineralocorticoid and. According to Komnenov et al. DOCA-salt induced hypertension in rats 6. Animal models of hypertension have been, and will likely remain, very useful in providing insights into the pathogenesis and novel treatment options of hypertension. A systematic review and meta-analysis was performed of a number of experimental studies of disease induction based on several animal models. Neuhof in 1912 first consummate the production of portal hypertension in animals . Hypertension is a multifactorial, polygenic disease that involves complex interactions between genetically determined homeostatic control mechanisms and environmental factors, 1 and its exploration thus requires availability of experimentally manipulable animal models. Compared to human models, an animal model is easily manageable, as compounding effects of dietary and environmental factors can be controlled. As the high-dose imatinib had had been well studied, we examined the anti-remodeling effects of a low-dose imatinib, and compared the treatment outcomes with The journal consistently attracts the most important and highly innovative papers from the current research; our commitment to rapid publication ensures that these are published in the fastest time possible. Crotalaria (monocrotaline) pulmonary hypertension: the Compared to human models, an animal model is easily manageable, as compounding e ects of dietary and environmental factors can be Pulmonary hypertension induced by monocrotaline 9. LDLR−/−Mice. Drug Discov Today Dis Models. Neurogenic hypertension in dogs 5. treatment of PAH. Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. . 2010;7: 83-88. J. Appl. The Several approaches across multiple species have been used to generate preclinical models of preeclampsia. Different experimental models have emerged to help in the understanding of the molecular and cellular mechanisms . animal models, chronic hypoxia, monocrotaline, pulmonary artery banding, pulmonary hypertension, right ventricular failure, right ventricular hypertrophy, SU5416 1 | INTRODUCTION Pulmonary hypertension (PH) is a multifactorial syndrome driven by remodelling of the pulmonary vascular bed (Humbert et al., 2019). Because of the polygenic nature of hypertension, numerous rat models have been developed including selective bred . In contrast, large animal models, which incur increased costs and complexities in housing and care, more closely mimic Reproducibility in animal models of hypertension: a difficult problem Jane F. Reckelhoff1,3,4* and Barbara T. Alexander2,3,4 Abstract In 2016, the National Institutes of Health mandated that all grant proposals enhance reproducibility through rigor and transparency. • Consume minimal quantities of compounds. Using an animal model, we sought to determine whether there was an increased activation/dysfunction of endothelin 1, the effect of endothelin 1 receptor-A blockade on hypertension and other manifestations of hemolysis, elevated liver enzymes, and low platelets syndrome. Zhao L. Chronic hypoxia-induced pulmonary hypertension in rat: the best animal model for studying pulmonary vasoconstriction and vascular medial hypertrophy. † Universidade Federal de Ciências da Saúde de Porto Alegre-UFCSPA . Introduction (2019), an HFHF diet induces . Pozzoli M, Cioffi G, Traversi E, Pinna GD, Cobelli F, Tavazzi L. Predictor of primary atrial fibrillation and concomitant clinical and hemodynamic Hypertension is one of the leading causes of disability or death due to stroke, heart attack and kidney failure. Overview of various animal models in pulmonary hypertension (PH) Various models Species Usage Dana Point (2008) Single-pathological-insult (SPI) models Monocrotaline (MCT) Rats Very common Group 1 Chronic hypoxia Rats/mice . Pathogenesis of primary chronic venous disease: Insights from animal models of venous hypertension John J. Bergan, MD, FACS,a Luigi Pascarella, MD, band Geert W. Schmid-Schönbein, PhD, LaJolla, Calif Background: Reflux of blood through incompetent venous valves is a major cause of the venous hypertension that underlies clinical manifestations of chronic venous disease, including varicose . 107 Animal model evaluation of a novel renal denervation system for future laparoscopic treatment of resistant hypertension Won Hoon Song1,2,* , Jinhwan Baik3,* , Sunchoel Yang 4, Eue-Keun Choi5, Sung-Min Park3, Chang Wook Jeong1 1Department of Urology, Seoul National University Hospital, Seoul, 2Department of Urology, Pusan National University Yangsan Hospital, Yangsan, 3Department of Taken together, the study shows for the first time that intermittent fasting can be beneficial in terms of reducing hypertension by reshaping the composition of gut microbiota in an animal model. Physiol. The best hypertension animal model should be characterized by the hemodynamics that is identical with that of the human cardiovas-cular system (EUROPEAN SOCIETY OF HYPERTENSION, 2003), and it should also develop adaptive chan-ges like those observed in humans with chronic hypertension. This review focuses on providing an overview of the role of RhoA/Rho kinase in currently available animal models of pulmonary hypertension.
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