paracetamol intramuscular dose

Mean pain scores at 30 minutes were 51.5 mm (22.9) in the intravenous paracetamol group and 54.2 mm (23.1) in the oral group (ANCOVA analysis; non-significant variance from ANOVA). Therefore, the total dose to be administered is: Total dose = (Weight of the patient in kg) x (dose of Drug) The most popular route of administration is oral, however, in some medical situations this route is unavailable, ineffective or associated with a high number of adverse reactions.That is why patients may receive drugs through parenteral means (this includes: subcutaneous, … What can it be used for? Calculation By Weight: 4.8kg x 10mg = 48mg, 4 times a day.. is 325-650 mg tablets once in every 4 to 6 hours or 1000mg tablets once in every 6 to 8 hours. Methods: A randomized, open-label, two-treatment, crossover, pharmacokinetic study of paracetamol dosed orally and intramuscularly was conducted. The Original Paracetamol Injectable. Intravenous paracetamol versus intramuscular pethidine in relief of labour pain in primigravid women. Measuring cups are suitable for dose volumes over 10 mL. Generic name: acetaminophen (injection) (a SEET a MIN oh FEN) Brand name: Ofirmev. in paracetamol group received a 100 ml intravenous infu-sion containing 1,000 mg of paracetamol single dose over 15 min, and all the women in the tramadol group were given tramadol hydrochloride 100 mg intramuscular single dose in upper and outer quadrant of gluteal region with a 2-ml syringe. The effective analgesic single dose of intravenous paracetamol in preterm infants is unknown. Composition: Paracetamol 150 MG. This is a general guide for the "average" sized child. Analgesic e.g. Each product may contain different strength of paracetamol so be sure to read the specific dosing instructions that come with the medication. About Reference Intervals. The main difference between the two drugs is that ibuprofen has anti-inflammatory effects, where paracetamol does not. Both drugs can be taken every four hours, and used to ease pain and control fevers. However, ibuprofen is more effective in easing inflammation and redness caused by arthritis, and in easing swelling caused by sprains and strains. Paracetamol Syrup Dosages. Manufacturer Name: Tablets India Limited. 3. Objective To assess the association between low-dose aspirin and the incidence of colorectal cancer (CRC), gastric cancer (GC), oesophageal cancer (EC) and gastrointestinal bleeding (GIB) in adults without established atherosclerotic cardiovascular disease. » The mean daily dose of paracetamol/tramadol was between 3.5 and 4.2 tab. The Original Paracetamol Injectable. The plasma paracetamol concentration at a known time point between 4 and 15 hours after a single overdose has been taken, indicates the likelihood of liver damage developing after 2 or 3 days. Comparative studies on efficacy of Mean pain scores at baseline (t=0) were 65.0 (15.8) in the intravenous group and 71.3 (15.6) in the oral group. Labels on liquid paracetamol products contain clear dosing instructions. IV paracetamol (15 mg/kg) is efficacious and equivalent to IV Propacetamol (30 mg/kg). Check if the dose has been quoted in mg. or ml. The maximum amount for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. This means that we can use a dose of at least 10 and a maximum of 15 mg. … 5.4 Monitor the individual’s condition throughout, recognise and adverse effects and take the appropriate action without delay. Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. The maximum dose per day is at 4,000mg for paracetamol. On the first day of life, he was accidentally given an intramuscular injection of 2 ml of a dilution of propacetamol chlorhydrate in 9% NaCl containing 800 mg (211 mg/kg) propacetamol, equivalent to 105.5 mg/kg paracetamol. 4 Calculate Pediatric Dose of Intramuscular and Endovenous drugs. Note A loading dose of 30 mg/kg (maximum 1.5 g) may be given provided there has been no paracetamol given within the preceding 12 hours. It contains paracetamol as an active ingredient. As mentioned above, your dosage depends on the type of product that you use. An initial dose of 20 mg/kg can be given if it is felt that maximum effect is needed quickly. A reduced dose of 1 g three times a day is recommended, with the duration of intake kept as short as possible. Adult: 33-50 kg: 15 mg/kg 4-6 hourly if needed. Depending on the route of administration, dosage forms come in several different types. Child: Full-term neonates and children <10 kg: 7.5 mg/kg as a single dose, at least 4 hourly. GENERIC NAME: Amikacin BRAND NAME: Amikin DOSE: USUAL PARENTERAL DOSAGE: IV, IM: ADULTS, ELDERLY, CHILDREN, INFANTS: 5 – 7.5 mg/kg/dose Inhibits protein synthesis in susceptible bacteria by binding to 30S ribosomal unit. Intravenous paracetamol stat dose can be used in post-operative patients who are unable to swallow, or unable to use or refuse suppositories. One patient in Group 1 did not receive the intramuscular dose of paracetamol on day 1 due to self-discharge from the hospital; one patient from Group 2 did not receive oral paracetamol on day 1 as the patient received multiple doses of paracetamol during the study period. If there is an allergic reaction. It is highly toxic to cats as their liver cannot break it down safely, and it is invariably fatal. This test therefore helps the doctor decide on the need for antidotal treatment to minimise the risk of such damage occurring. Child dosing of paracetamol. Also, while it’s just my opinion, there is actually a benefit for having this medication he supplied and 325 mg tablets instead of scored 650 mg tablets. Alhashemi et al. Evidence-based guidelines recognize the potential value of combination analgesics in specific situations. A healthy adult may take a maximum dose of eight 500mg tablets of paracetamol in a day with at least 4 hours in between each dosage. It is highly toxic to cats as their liver cannot break it down safely, and it is invariably fatal. (2006)24 80 R, DB, active comparator pain (tonsillec-tomy) SD trial in 80 children (age 3 –15 years) IV paracetamol 15 mg/kg is efficacious and equivalent to IM me- For example the Dose of Paracetamol is 10-15 mg / Kg / dose. A maximum of 3-4 doses of paracetamol for babies within two to three months may be given under consultation from a doctor. Maternal vital signs were monitored and labor pain was assessed using the numerical rating scale. At a standard dose, paracetamol only slightly decreases body temperature; it is inferior to ibuprofen in that respect, and the benefits of its use for fever are unclear. Using more Paracetamol (Cypa) could cause damage to your liver. Hence we aimed to compare the antipyretic efficacy of intravenous (i.v.) Interventions: multiple or single doses of study drug (paracetamol or NSAID) were administered perioperatively (defined as the first dose administered within an hour prior to induction or following wound closure) by any systemic route (oral, rectal, intramuscular, or intravenous). Diclofenac + Paracetamol is a prescription medicine. As Paracetamol 500 MG Tablet is an OTC tablet, up to 500mg dose, many people tend to use it randomly, and this is not good. One group received intramuscular 600 mg paracetamol and the other 100 mg tramadol at recruitment with rescue dose at least 3 h apart. Based on the dose of paracetamol ingested (mg/kg body weight): Less than 150 mg/kg - unlikely. The volume of distribution of paracetamol is approximately 1 L/kg. From table: 0.8 ml – 1 ml, 4 times a day. OR. 1. Give one dose of paracetamol in clinic for high fever (38.5°C or above) Refer URGENTLY to hospital • Any general danger sign or • Stiff neck VERY SEVERE FEBRILE DISEASE Give oral co-artemether or other recommended antimalarial Give one dose of paracetamol in clinic for high fever (38.5°C or above) >50 kg: 1 g 4-6 hourly if needed. The infant was then transferred to our unit. Max 4g daily. In higher doses however, it can be toxic to dogs as well so always carefully follow the instructions from your veterinarian. omized to receive a single 600 mg dose of paracetamol either as syrup or intramuscular injection on day 0 followed by a single dose administered by the alternative route on day 1. All patients were included in the pharmacokinetic analysis Therefore, pain may be effectively treated while toxicity is reduced due to lower doses. Note A loading dose of 30 mg/kg (maximum 1.5 g) may be given provided there has been no paracetamol given within the preceding 12 hours. Consult product literature. The maximum dose per day is at 4,000mg for paracetamol. The optimal dosage of Diclofenac + Paracetamol is largely dependent on the individual's body weight, medical history, gender and age. Usual Adult Dose for Fever . Uses. pathway, and therefore an oral dose is approximately half as potent as an intramuscular dose. Paracetamol 1g orally or rectally every 4 to 6 hours. Regular paracetamol use linked to higher blood pressure, study finds Tesla Cybertruck Concept Converts Pickup Into A Capable Catamaran Francis Ngannou tipped to earn £29.5million from Tyson Fury boxing fight Paracetamol may relieve pain in acute mild migraine but only slightly in episodic tension headache. Paracetamol rarely causes side effects if you give it in the right doses. Repeated Dose Toxicity Study of Paracetamol Injection (1000 mg/4 ml) in Rabbits The objective of this study was to assess the local and systemic toxicity in rabbits from 14 days repeated administration of Paracetamol Injection (1000 mg/4 ml), prepared as per the present invention with a special emphasis on identifying target organs toxicities. Brand: Tablets India Limited. The paracetamol dose should be prescribed as accurately as possible, however, in practice increments of 0.5 mL are often used. Paracetamol, ibuprofen, or aspirin are adequate for most cases of dental pain and an opioid is rarely required. Paracetamol can NEVER be used in cats. Paracetamol dosage for infants is best given in the form of syrup or suppositories in accordance with their weight, as paracetamol syrups come in different strengths. in cold and flu remedies. Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Max. Under 50 kg: 15mg/kg by intravenous (IV) infusion over 15 minutes every 4 to 6 hours. Paracetamol very rarely causes side effects if you take it at the right dosage. Dolo Tablet is a pain-relieving medicine. Warnings. Twenty-one adult patients with uncomplicated … On anamnesis, the mother reported having severe low back pain 2 weeks earlier, for which she received a single dose of IM diclofenac Footnote 1 at 35 weeks of gestational age followed by a 5 day course of paracetamol [dosage not stated; in-utero exposure to paracetamol and diclofenac). What is the recommended dosage? Paracetamol Tablets are 500 mg, analgesic and antipyretic, similar to aspirin and therefore a suitable alternative for aspirin-sensitive patients. Children should be treated with the same doses and regimen as adults; however, the quantity of intravenous fluid used should be modified to take into account age and weight, as fluid overload is a potential danger. However, this applies only when an adequate dose of each analgesic is used. What is the recommended dosage? Calculate the Dose of Paracetamol. General Dosing: 1 month - 18 years 15 mg/kg per dose (maximum 1 g) every four hours; maximum 75 mg/kg per day (without exceeding 4 g) for 48 hours, maximum of 60 mg/kg per day (without exceeding 4 g) thereafter. Use clinical judgement to adjust the dose of oral paracetamol in people with risk factors for hepatotoxicity, such as liver disease or body weight less than 50 kg. The normal dose of paracetamol is one or two 500mg tablets at a time, up to four times in 24 hours. The dosage recommendations of paracetamol products available over-the-counter may vary – products produced by different manufacturers may recommend specific dosages which may differ from similar products. Paracetamol ... Intramuscular injection – into muscle; Subcutaneous injection – under the skin . ₹ 13.9/ Vial Get Latest Price. The recommended way to combine these drugs is to take a dose of ibuprofen and then wait for four hours to take a dose of paracetamol and so on. If risk factors are present:; Consider reducing the dose of paracetamol to a maxiumum of 3 g in 24 hours (for example 1 g three times daily) or use 15mg/kg every 4–6 hours (maximum of 60 mg/kg in 24 hours) as a guide. QUICK DETAILS: DINPARA Contents: • Each active substance is 600 mg of paracetamol. Paracetamol can NEVER be used in cats. [29920] Start within 1 hour for septic shock or within 3 hours for sepsis-associated organ dysfunction without shock. Distribution. The normal dose of paracetamol is one or two 500mg tablets at a time, up to four times in 24 hours. If you drink more than three alcoholic beverages per day, talk to your doctor before taking Paracetamol (Cypa) and never use more than 2 grams (2000 mg) per day. Fever, Mild to moderate pain. The present invention relates to low volume intravenous injections of paracetamol or its pharmaceutically acceptable salt and method of preparation thereof. If the dose on the MAR form is different to the prescription. In higher doses however, it can be toxic to dogs as well so always carefully follow the instructions from your veterinarian. Paracetamol Dosage for Adults and Older Children. Side effects. Form: Injection. 1 Dose calculations are based on the weight in the middle of each band.. 2 Ampoule volume has been rounded up to the nearest whole number.. Children. If you’re referring to 325 mg tablets, 325 mg is considered the starting dose for people ages 12 and older. Medically reviewed by Drugs.com on Jul 14, 2021. While taking this medicine you should not take other medicines containing paracetamol. It is taken in light to moderate pain and the condition of fever, such as headache, toothache, cold, … Secondary and off-label uses of Diclofenac + Paracetamol have also been mentioned below. If doubt arises over the dosage e.g.. because of the child's size or an underlying medical condition, check the dosage in the eBNF.. At a standard dose, paracetamol only slightly decreases body temperature; it is inferior to ibuprofen in that respect, and the benefits of its use for fever are unclear. For paracetamol, the usual dose for adults is one or two 500mg tablets up to four times in 24 hours. 3.2 Calculate Pediatric Antibiotics Dose; 3.3 Pediatric Dose Calculation in Special Situations; 3.4 Pediatric doses of drugs in drops. The maximal plasma concentration (Cmax) of paracetamol observed at the end of 15-minutes intravenous infusion of 500mg and 1 g of Paracetamol 10 mg/ml Solution for Infusion is about 15μg/ml and 30 μg/ml respectively. For Adult (body-weight 50 kg and above) 1 g every 4–6 hours, dose to be administered over 15 minutes; maximum 4 g per day. This study attempted to compare analgesic effect of intravenous paracetamol with intramuscular pethidine in reducing labour pain. 0.5–1 g every 4–6 hours; maximum 4 … The dose should be individualised and will depend on the severity of the condition. In case you do, refrain from taking two doses together to make up for the missed one. This allows your body to rest and recuperate from the effect these painkillers have on your body. Dose based on codeine (1-2 mg/kg q8-12 hrs) but limited by acetaminophen (not to exceed 10-15 mg/kg q8-12hrs) Example: 1-2 tablets listed at left per 30 kg dog q8-12hrs Canine Quick Dosage Sheet The International Veterinary Academy of Pain Management (IVAPM) is the leading forum and educational source for veterinary professionals interested Pain intensity before administering drug was Therapeutic doses of paracetamol do not exacerbate stable chronic liver disease, and metabolism of paracetamol is normal in these patients. 3.5 Adjust Dosage of Medications. Let’s call it X ml … Since 1968, AEKNIL Injection has been used by doctors for the treatment of fever of unknown origin and for symptomatic relief of pain. This study was, therefore, undertaken to compare the pharmacokinetics of paracetamol when administered by two routes, viz, intramuscular and rectal, in children undergoing minor surgery. Therapeutic Effect: Interferes with protein synthesis of susceptible microorganisms. For children aged 12-15 years: 480-750 mg every 4-6 hours up to a maximum of four doses daily. Paracetamol may relieve pain in acute mild migraine but only slightly in episodic tension headache. Setting Clinical Data … 3.1.1 Calculate the Dose of Paracetamol. Dosing simulations of intramuscular and oral syrup paracetamol administered at a dose of 600 mg every 4 h showed that this regimen reached therapeutic steady state concentrations but with a delayed onset of action. Dicyclomine (Tormina) ... Usual Adult Paracetamol (Tormina) Dose for Fever: General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally. Studies evaluating the safety of paracetamol, NSAIDs and opioid analgesics during pregnancy and breastfeeding are limited and there are no prospective, comparative studies; therefore, further research is needed to clarify the safety of these drugs. Patients were randomly assigned to receive oral paracetamol 1,000 mg, intravenous paracetamol 1,000 mg, or intramuscular diclofenac sodium 75 mg supplied from the hospital pharmacy free of cost to the patients. The therapeutic target level of paracetamol was assumed to be 10–20 mg/l [23, 24]. Recommended doses of paracetamol are: For adults and children aged 16 years and older: 500 mg-1 g every 4-6 hours up to a maximum of 4 g daily. It is advised to be guided by the doctor’s prescription and never to exceed the prescribed dosage. OObjectives: Although paracetamol is a widely accepted and safe analgesic, guidelines bjectives: regarding its definite analgesic dose are lacking. The formulations provide high concentration of paracetamol or its pharmaceutically acceptable salt in a solvent system of the present invention which can be administered not only through intra- muscular & intravenous … But how many ml is 48mg? Max: 4 g daily. Mandema and Stanski39 studied adult patients (n = 522) given a single oral or intramuscular dose of placebo or a single intramuscular dose of 10, 30, 60, or 90 mg ketorolac for pain relief after orthopaedic surgery. Paracetamol can be useful to manage pain in dogs. What can it be used for? If people experience allergic reactions to this pill, then that means that they should not take it. A healthy adult may take a maximum dose of eight 500mg tablets of paracetamol in a day with at least 4 hours in between each dosage. All the women in paracetamol group received a 100ml intravenous infusion containing 1000 mg of paracetamol single dose over 15min, and all the women in the tramadol group were given tramadol hydrochloride 100mg intramuscular single dose in upper and outer Paracetamol/Tramadol association: the easy solution for mild-moderate pain chronic pain; » 6 studies considered the duration of treatment was 4-13 weeks and a total of 1 890 patients, affected by chronic musculoskeletal pain. The maximum amount of paracetamol for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. A comparison between the pharmacokinetics of oral syrup and intramuscular paracetamol given to patients with acute falciparum malaria and high body temperature was performed. Side effects in children. The availability of many pharmaceutical form – oral, intramuscular, intravenous, transdermal, and rectal – and no requirement for dose adjustment in the elderly or patients with renal impairment are among the leading reasons for the widespread use of diclofenac (Todd & Sorkin, Reference Todd and Sorkin 1988). Lidocaine 1.0 mg/kg IV Loading dose Administer slowly Drug Species Dose (mg/kg) Route Dosing Interval Comment Piroxicam Most 0.5 PO, IM 12 Chronic pain Buprenorphine Most species 0.01–0.05 IM 8 Mixed agonist/antagonist Butorphanol Most species 0.5–0.75 IM, IV 12 Primary kappa action Fentanyl Cockatoos 0.2 SC May have excitement phase Red-tailed AEKNIL Injection is the first Paracetamol solution for Injection in the world at 150 mg/ml. For adults Paracetamol 150 MG Injection the general dose for fever and pain. 4.2 Drug calculation with Reconstitution All the women in paracetamol group received a 100 ml intravenous infusion containing 1,000 mg of paracetamol single dose over 15 min, and all the women in the tramadol group were given tramadol hydrochloride 100 mg intramuscular single dose in upper and outer quadrant of gluteal region with a 2-ml syringe. Caregivers should be strongly encouraged to use a syringe to measure the dose. Common drug dose estimates in children. The maximum amount of paracetamol for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking more paracetamol could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking paracetamol and never use more than 2 grams (2000 mg) per day. Max: 3 g daily. 15 mg/kg every 4–6 hours, dose to be administered over 15 minutes; maximum 60 mg/kg per day. The recommended paracetamol dosing for adults and children 12 years and over is 500 to 1000mg every four to six hours as necessary, with a maximum of 4000mg in any 24 hour period. Also, if you insist on getting high from codeine tablets again google "codeine cold water extraction method" and follow the instructions correctly. In patients with severe disease, however, the elimination half-life can be prolonged. Intravenous paracetamol was given as an infusion over 15 minutes. Paracetamol is sold both on its own and in combination with other medications e.g. • The other ingredients are: polyethylene glycol 400, sodium metabisulfite and water for injections. This is a common medication and it’s also quite toxic to the liver in high doses. A one-off deep intramuscular injection can be used to relieve the symptoms of acute gout. A dose of 30 mg/kg 8 hourly gives levels in the therapeutic range. IV paracetamol produced a mean of 0.6C/hour with 70% of patients below 38C. You should always leave four hours between doses. [63245] The FDA-approved labeling recommends 50 to 75 mg/kg/day IV or IM divided every 12 hours for serious infections in pediatric patients. Paracetamol can be useful to manage pain in dogs. 3g daily. General Dosing: 1 month - 18 years 15 mg/kg per dose (maximum 1 g) every four hours; maximum 75 mg/kg per day (without exceeding 4 g) for 48 hours, maximum of 60 mg/kg per day (without exceeding 4 g) thereafter. Urgent warning to millions of Brits as paracetamol increases heart attack risk. ... To assess the use of single dose of paracetamol intravenously in … 10 – 15mg/kg per dose, 4 times a day. Depending on the route of administration, dosage forms come in several different types. AEKNIL Injection is the first Paracetamol solution for Injection in the world at 150 mg/ml. Paracetamol Injection 600mg,USP. pain, etc. If you drink more than three alcoholic beverages per day, talk to your doctor before taking paracetamol and never use more than 2 grams (2000 mg) per day. Different dosage regimens were investigated based on a maximum dose of 4 g paracetamol per day and the available paracetamol products (i.e., 500 mg oral tablet and 300 mg/2 ml for injection). It is used for reducing fever and relieving pain including toothache, headache, migraine, muscle ache, period. 76 examined the effects of paracetamol (3 g d –1), ibuprofen (1200 mg d –1) and a combination of the two (ibuprofen 600 mg/paracetamol 1.5 g daily, or twice this dose) for chronic knee pain in a parallel-group RCT of 892 patients. Strength: 150 MG. Packaging Size: 2 ml in 1 vial. A (Paracetamol)—100 women and Group B (Tramadol)— 100 women. diclofenac in adult patients presenting with fever to the ED. DINPARA Character: •DINPARA is a clear, colorless solution, free from visible particles. The most popular route of administration is oral, however, in some medical situations this route is unavailable, ineffective or associated with a high number of adverse reactions.That is why patients may receive drugs through parenteral means (this includes: subcutaneous, … In this example we will use a 15 mg dose in a child weighing 12 kg. Since 1968, AEKNIL Injection has been used by doctors for the treatment of fever of unknown origin and for symptomatic relief of pain. Non-steroidal anti-inflammatory drugs may have a more rapid speed of onset than paracetamol because of a smaller Teq. The availability of a safe and effective pharmacological therapy to reduce procedural pain in preterm infants is limited. By rectum. It is important to make sure that the other medicines in combination products can be taken in pregnancy and that you do not take more than the … Example: 3 months baby of 4.8 kg. 24g of Paracetamol is generally accepted to be a fatal dose. The lowest amount of Paracetamol to cause death was found by one study to be 10g. As for Paracetamol of 500mg per tablet, it is generally recommended to take no more than 8 tablets (500mg) within 24 hours, and 24 to 30 tablets taken at one time can lead to overdose or even death. One recent fixed-dose combination analgesic product combines tramadol, a centrally acting weak opioid analgesic, with low-dose paracetamol. Adult dosing of paracetamol. paracetamol and intramuscular (i.m.) Syrup content 250mg PCM / 5ml. Baseline oral temperature was recorded at enrollment. More than 250 mg/kg - likely. Dose based on codeine (1-2 mg/kg q8-12 hrs) but limited by acetaminophen (not to exceed 10-15 mg/kg q8-12hrs) Example: 1-2 tablets listed at left per 30 kg dog q8-12hrs Canine Quick Dosage Sheet The International Veterinary Academy of Pain Management (IVAPM) is the leading forum and educational source for veterinary professionals interested Thus, we will be taking both the dose of ibuprofen and of paracetamol every eight hours. Paracetamol 150 Mg Fevastin Injection, 2 Ml In 1 Vial. The proposed dose regime for Pracetam 400 mg/ml Oral Solution for Pigs containing paracetamol involves treatment at a dose level of 30 mg paracetamol/kg bw/per day for a maximum of five days administered in the drinking water (oral administration). More than 12 g total - potentially fatal." 10 A single dose of 30 mg/kg of paracetamol at bedtime can increase the amount of sleep for the whole family when a child has mild acute infection, but the danger of repeating this dose has to be emphasised. Intramuscular Dosage And Administration In Adults. If … Dosage forms: intravenous solution (10 mg/mL) Drug class: Miscellaneous analgesics. For Adult. Design Cohort study with propensity score matching of new-users of aspirin to non-users. Intravenous. Here is the usual dosing for adults and children age 12 years and above. Combining a non-opioid with an opioid analgesic can provide greater relief of pain than either analgesic given alone. Intramuscular corticosteroids are not specifically licensed for the treatment of gout. Written by Cerner Multum. Administer by infusion over 15 minutes. Use clinical judgement to adjust the dose of oral paracetamol in people with risk factors for hepatotoxicity, such as liver disease or body weight less than 50 kg. If risk factors are present:; Consider reducing the dose of paracetamol to a maxiumum of 3 g in 24 hours (for example 1 g three times daily) or use 15mg/kg every 4–6 hours (maximum of 60 mg/kg in 24 hours) as a guide. In paediatric surgical patients, recommended doses of intravenous paracetamol 15 mg/kg were not significantly different from propacetamol 30 mg/kg for the treatment of pain, and showed equivocal analgesic efficacy compared with intramuscular pethidine 1 mg/kg in several randomized, active comparator-controlled studies.

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